Osteoclast相关论文
目的:构建髓系细胞特异性Clcn7-G763R突变的骨硬化小鼠模型，并进行表型研究。方法:构建条件性敲入Clcn7基因p.G763R错义突变小鼠，并......
目的 研究miR-216b在破骨细胞分化中的功能和靶基因,探讨其对破骨细胞胆固醇外流的影响.方法 建立RANKL刺激诱导RAW 264.7破骨细胞......
背景:白细胞介素1是一种重要的促炎细胞因子,已被证实在调节骨炎症和骨重建中发挥重要作用.有研究表明,白细胞介素1α可诱导MC3T3-......
背景:自噬对维持细胞稳态和应激敏感性有重要作用,作为细胞清除受损细胞器并实现细胞成分再循环的一种重要方式,在骨代谢中发挥着......
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The steroid hormone 1,25-dihydroxy vitamin D3 [1α,25-(OH)2D3] plays a key role in calcium homeostasis and bone metaboli......
Particulate and ion forms of CoCr-challenged preosteoblasts promote osteoclastogenesis and osteolysi
Using an experimental mouse model of prosthesis failure,the current study investigated the interactive behavior of the p......
NF-κB signal mediates the protective effects of lithium chloride against wear-debris-induced inflamm
Osteoclast and inflammation responses are crucial for peri-implant osteolysis (PIO) which is leading cause of aseptic lo......
Aseptic loosening after joint replacement is primarily caused by wear particle-induced osteolysis,which shortens the lif......
Objective: Study of cobalt nanoparticles toxicity of osteoclasts and biological activity.Methods: Mononuclear macrophage......
EGFL7 is expressed in bone microenvironment and mediates the migration of endothelial cells and angi
Angiogenesis plays a pivotal role in bone formation, remodeling and fracture healing.The regulation of angiogenesis in t......
Objective: Tumour necrosis factor receptor-associated factor 6(TRAF6)is an essential component of the signalling complex......
Myricitrin is a botanical flavonol glycoside,extracted from leaves of Myrica cerifera and other plants.Abundant evidence......
The aim of this study was to assess the effect of rifampin on osteoclastogenesis and titanium(Ti)particle-induced osteol......
Low-molecular-weightfucoidaninhibitsthedifferentiationofosteoclastsandtreatosteoporosisin
Fucoidanisatypeofsulfatedpolysaccharideisolatedfromseaweed.Inthisstudy,weusedovariectomizedSprague-Dawley(S-D)ratsweretr......
Asepticloosening(AL)isthesinglemostcommoncomplicationoftotaljointarthroplasty.Thecritical factormaycontributetoloosening......
Effect of Eucommia Ulmoides and Fructus Psoraleae on expression of MMP3/OPN pathway proteins of ovar
Objective Investigate effect of the compound Chinese medicine on osteoclasts(OC)apoptosis and expression of MMP3-OPN-p53......
Disturbed MEK/ERK signaling increases osteoclast activity via the Hedgehog-Gli pathway in postmenopa
Postmenopausal osteoporosis is a worldwide health problem and is characterized by increased and activated osteoclasts....
Background:Estrogen deficiency is an important reason for osteoporosis in postmenopausal women.Previous studies confirme......
CDK9inhibitionsuppressedRANKLinducedosteoclastformationinvitroandpreventsboneerosionin
Purpose:Osteoclast is responsible for bone resorption,which plays a pivotal role in bone homeostasis and pathologic bone......
Objectiv: Advanced glycation end products(AGEs)affect bone remodeling with aging and at an accelerated rate in diabetes.......
Oridonin inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the MAPKs
Objective.Oridonin, an active diterpenoid compound from Rabdosia rubescens,has effects of anti-tumor,treating multiple m......
The mechanisms of PIM kinase inhibitor,SGI-1776 free base,in treating myeloma associated bone diseas
Objective The PIM kinase family which includes PIM1,2 and 3 have an essential role in cell growth and survival,expressin......
Enhanced osteoclast formation and function play essential role during postmenopausal osteoporosis.Many cytokines have be......
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The relevancy of long non-coding RNAs(lncRNAs)-transcription factors(TF)expression network of osteoc
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Bone remodeling involves synthesis of organic matrix by osteoblasts and bone resorption by osteoclasts.Recently, anti-di......
studies have reported mefformin, an insulin-sensitizer drug commonly used for type 2 diabetes, could enhance differentia......
Effects of total lignans from Du-Zhong (Eucommia ulmoides Oliv) cortex prevent bone loss in vivo and
Our previous study demonstrated that the potential protective effects of DuZhong on ovariectomy (OVX) induced osteoporos......
AspirininhibitsosteoclastogenesisbysuppressingtheactivationofNF-κBandMAPKsinRANKL-induce
Aspirinisacommonlyusedmedicineasaneffectiveantipyretic,analgesicandanti-inflammatorydrug....
FY-11 suppresses RANKL-induced osteoclast formation by attenuating NF-κB and the expression of DC-ST
Objective: Bone formation by osteoblasts and bone re sorption by osteoclasts contributes to the balance of bone remodell......
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Oleanolic acid (OA) exerts an osteoprotective effect in ovariectomy-induced osteoporotic mice and in
Osteoclast-induced bone disordering diseases, such as osteoporosis, are quite prevalent in modem society.However, the cu......
Sinomenine attenuates lipopolysaccharide-induced osteolysis via the inhibition of NF-κB signaling pa
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Osthole exerts an osteoprotective effect in mice model of 5/6 nephrectomy through inhibition of oste
OBJECTIVE:To investigate the effects of osthole on osteoclast formation and bone loss in mice model of 5/6 nephrectomy.M......
Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through pro
Objective:Periarticular and subchondral bone erosion is a significant feature of Rheumatoid Arthritis (RA).It results fr......
Osteoprotective effects of osthole in mice model of 5/6 nephrectomy through inhibiting osteoclast fo
Objective: To investigate the effects of osthole on osteoclast formation and bone loss in mouse model of 5/6 nephrectomy......
Anti-diabetic drug metformin has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiatio......
Background: Osteoporosis is accompanied by an increase in bone marrow adipose tissue.Bone marrow adipogenesis has emerge......
Bisphosphate protect cartilage by reducing chondrocyte apoptosis and reduce bone lose by suppressing
Objective To investigate the effects of bisphosphate on joint cartilage in rat adjuvant arthritis.Method 160 seven-week-......
Bisphosphate Protect Cartilage by Reducing Chondrocyte Apoptosis And Reduce Bone Lose by Suppressing
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Objective: To investigate the effects of osthole on osteoclast formation and bone loss in mouse model of 5/6 nephrec......
Osteoprotegerin disrupts peripheral adhesive structures of osteoclasts by modulating Pyk2 and Src ac
Osteoprotegerin has previously been shown to modulate bone mass by blocking osteoclast maturation and function.The d......
LGR4 is a receptor for RANKL that negatively regulates osteoclast differentiation and bone resorptio
Tumor necrosis factor superfamily member 11 (TNFSF11;also known as RANKL) regulates variety of physiological or path......
目的探讨miR-187-5p通过RANKL/NFκB信号通路对骨质疏松症中破骨细胞活性的影响及机制分析。方法使用小鼠巨噬细胞264.7细胞株（RAW2......
最近在Journal of Molecular Signaling发表的题为“Dramatic inhibition of osteoclast sealing ringformation and bone resorpt......
